The book was originally published in 1985, so it is a little bit out of date - neuroscience having moved on a bit in the intervening 25 years. Even knowing this before I started I still couldn't help feeling a little disappointed throughout the book in the lack of investigation in to the patients conditions. Many of these conditions are both fascinating and sad at the same time and I kept wanting Sacks to do something to help - instead he just documents and quotes other peoples observations of similar patients! True, some of the patients get help, but it always seems haphazard. I wanted this to be another Phantoms of the Brain and it was just 20 years too early.